QUOTE(McMark @ Jun 7 2012, 12:47 AM)
If the idle mixture adjustment screw has no effect, or can be closed all the way, there are three things that come to mind.
1. The idle jet is clogged and isn't allowing fuel to pass, so the screw has no effect.
2. The venturi is too small and the engine is creating enough vacuum at idle to engage the main jets.
3. The ignition system for that cylinder isn't working correctly and cutting fuel back doesn't have an effect because the spark plug isn't firing correctly anyway.
A couple more:
A vacuum leak and your not pulling air through the idle circuit.
Float level too high and your spilling/pulling fuel over from the mains
Butterflies open too far at idle and your pulling fuel from the progression ports.
If I was a betting man I'd go with Mark's first description.