Take this as a thought exercise.
When I have engine issues I always follow this order in troubleshooting
1) Compression - do I have it? In all honesty, I usually skip this under the assumption that things are fine unless there is reason to question it.
2) Ignition - do I have spark and at proper time
3) Fuel - is mixture right?
Spark is weird on these old cars, it's not like coil on plug in modern cars that is high intensity and precisely controlled. Coils get weak, some wires get high resistance and can cause 1 cylinder to spark earlier or later than the others, distributor lobes wear, etc. I once had a distributor slip the timing over a period of time because I didn't tighten the holding bolt enough.
A slightly stretched intake valve or a valve adjuster vibrated loose can close up the valve clearance leading to a slight intake leak that either doesn't get good compression or allows the combustion flame front to leak by the valve slightly (Only needs to be minuscule since combustion event is at high pressure) and get's access to the otherwise incoming fuel charge in the manifold and causes backfiring in just one cylinder. Highly unlikely, but could account for a 1 cylinder variation.
Moral of the story: If you haven't checked valves and ignition don't discount the possibilities just yet.
I always kept records of what my carb idle adjustment screws and air bypass screws were set at. That way you have a know "good" setting to return to if there is any doubt about whether a carb adjustment backed out over time. I always documented them as # of turns from full seated position. That way you can screw them in and reset without much risk of disturbing the settings.
Likewise I always kept record of my valve adjustments over time - if you keep having to loosen a valve clearance, it's stretching. Usually happens with exhaust but again could be either.
I personally found record keeping to be important. Just kept it all in a Moleskine type journal before Moleskine's ever became cool.
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