Agreed. Down and dirty. I finished getting my rear floor pan out and it took quite a long time to get everything drilled. Get the car as high into the air as you can SAFELY go.
At the risk of telling you what you may already know, I do have a few suggestions that I figured out trial and error. If this is all redundant for you, disregard. This is simply stuff I didn't know I needed to know when I did mine. If I'd known this stuff before, it would have made it much easier.
Buy one or two of these:
http://cgi.ebay.com/2-3-8-inch-HSS-Spot-We...1QQcmdZViewItemAnd one or two of these:
http://cgi.ebay.com/NEW-DEWALT-1924-PILOT-...1QQcmdZViewItemI found that the 5/16" bits I bought were just a tiny bit to small if you didn't get on the weld exactly center. If you are good, you might be able to make the 5/16" bits work. Well, you can make them work regardless, it will just take longer if you are not experienced. I made it work and I am not "good".
Use the spot weld bits for the longs or anywhere you cannot afford to go all the way through all the metal. These are designed with a really small, shallow pilot so the cutting in the center is minimal. Use the Dewalt style regular bits for the areas like the center tunnel and firewall sections where you should go through the metal. Yes, go all the way through with the pilot portion of the bit. Dewalt and Rigid bit have a nice flat outer section like a spot weld bit but with a long pilot, which is great for this. I wouldn't go all the way through with the 3/8" part, just the pilot. The advantage here is that when you go to rosette weld the floor back in, you can do these spots from above. Plus, you don't have to drill holes in your new pan. Make sense? PM me if you need pics. I don't have any now but could get you some.
Use cutting oil and a regular variable speed drill. Doesn't have to be a "spot weld drill". Just go slow. These bits cut amazingly well but should not be used fast. Use pressure if you have to, not speed. The cutting oil (3n1) will make them last a long time.
Good luck. Be methodical and patient and you will make it happen. If you get frustrated, walk away for a while. Get in the zone, listen to music, whatever. Just realize that this is "down and dirty work", as was mentioned.